Rob Completes PhD Viva

Congratulations to Dr Robert Ives, who has successfully completed his PhD viva! Rob joined our group at Durham Univeristy, having previously completed a MChem degree at the Univeristy of York, before moving back to York with the group last year. Thanks to Drs Sam Thompson and Allegra Franchino for carrying out Rob’s viva.

Since leaving the group, Rob has joined the Bonfio Lab at the Univeristy of Cambridge as a postdoctoral researcher, where he investigates supramolecular biochemistry.

Yuzhen's PhD Success

Yuzhen Wen has passed her PhD viva – congratulations, Yuzhen! We are grateful to Prof Stephen Goldup and Dr Will Brittain for their efforts as her PhD examiners.

Yuzhen started her chemistry education with a BSc degree at Tianjin University. She then completed a MSc research degree in our group at Durham University, before moving on to a PhD with the support of China Scholarship Council funding. Since completing her PhD, Yuzhen has return to China to carry out reserach in the Jiang Group at Shanghai Tech.

Thesis Prize for Juliet

Congratulations to final-year PhD student Juliet Barclay who was selected by the Chemistry Department at York as a winner of the KMS Memorial Prize. The prize is awarded annually and recognises excellence in research by students in the third year of their PhD. Juliet was selected on the basis of her investigations into state-independent electrolytes. She recently returned from a placement at NIMS, Japan, where she was investigating the applications of her materials in memory devices. Congratulations Juliet!

Shapeshifting Double Whammy

We’ve published a pair of papers in Chemical Science on the shapeshifting rearrangements of bullvalenes. The first paper uses principal moments of inertia and exit vector analyses to define exactly what shapes are accessible from the bullvalene scaffold. The second paper demonstrates how the shapeshifting equilibrium network of a bullvalene can be perturbed by the E-to-Z isomerisation of a pendant functional group. Congratulations to all of the co-authors involved!

Will Passes PhD Viva

Congratulations to (Dr!) Will Maturi, who completed his PhD today! Will joined the group in 2020 after completing an MChem degree at Durham University and his PhD research has investigated fluxional molecules and their noncovalent bonding interactions. Thanks to Profs Paul Lusby and AnnMarie O’Donoghue for carrying out Will’s viva.

Promeet Completes PhD

Congratulations to Promeet Saha who passed his PhD viva this week! Promeet joined our group initially as a summer student, then for a final-year undergraduate project before starting his graduate studies in 2020. His thesis deals with overcrowded systems that exhibit ruptured aromaticity or undergo photocyclisations. Good luck to Promeet in his next step as a postdoctoral researcher with Rafal Klajn at the Institute of Science and Technology Austria.

Fluorescent Rotors Under Pressure

Our latest paper is out in JACS, describing the use of high-pressure crystallography and high-pressure optical spectroscopy to investigate how packing influences the optoelectronic properties of organic chromophores.

Thanks to our excellent collaborators Prof Stephen Moggach (Univeristy of Western Australia) and Prof Anita Jones (University of Edinburgh).

Abstract: To develop luminescent molecular materials with predictable and stimuli-responsive emission, it is necessary to correlate changes in their geometries, packing structures, and noncovalent interactions with the associated changes in their optical properties. Here, we demonstrate that high-pressure single-crystal X-ray diffraction can be combined with high-pressure UV–visible absorption and fluorescence emission spectroscopies to elucidate how subtle changes in structure influence optical outputs. A piezochromic aggregation-induced emitter, sym-heptaphenylcycloheptatriene (Ph7C7H), displays bathochromic shifts in its absorption and emission spectra at high pressure. Parallel X-ray measurements identify the pressure-induced changes in specific phenyl–phenyl interactions responsible for the piezochromism. Pairs of phenyl rings from neighboring molecules approach the geometry of a stable benzene dimer, while conformational changes alter intramolecular phenyl–phenyl interactions correlated with a relaxed excited state. This tandem crystallographic and spectroscopic analysis provides insights into how subtle structural changes relate to the photophysical properties of Ph7C7H and could be applied to a library of similar compounds to provide general structure–property relationships in fluorescent organic molecules with rotor-like geometries.

Aisha and Rabia Win at EWOC Europe

Well done to PDRAs Dr Aisha Bismillah and Dr Rabia Ayub who won presentation and poster prizes at the Empowering Women in Organic Chemistry Europe Conference!

Burhan Passes PhD Viva

Congratulations to Burhan Hussein who recently completed his PhD viva! Burhan’s PhD was supported by the Soft Matter and Functional Interfaces CDT, as well as the Natural Sciences and Engineering Research Council of Canada (NSERC). His thesis on the ‘Control of Dynamic Supramolecular Systems’ was examined by Profs Jon Steed and Guillaume De Bo.

Since leaving the McGonigal Group, Burhan has retured to Canada as an NSERC Postdoctoral Fellow in the Lumb Group at McGill University where he is investigating silanes as cancer therapeutics.

Dynamic Chirality in Nature Chemistry

We have published a paper in Nature Chemistry describing the dynamic inversion of carbon-centred stereochemistry in fluxionally chiral carbon cages. Watch the video below for an animated summary.

We showed that with appropriate substitution patterns, the rapid and reversible Cope rearrangement of barbaralane carbon cages interchanges pairs of enantiomers. The sp3-C stereocentres in their structures are inverted.

Typically, inverting sp3-C stereocentres requires high-energy bond-breaking and bond-making steps through step-wise intermolecular reactions with external reagents. But the barbaralane stereochemistry is intrinsically dynamic. Our paper shows the consequences of this dynamic bonding: the cage adapts its stereochemistry in response to its environment (through covalently attached groups or associated ions); its rearrangements can be stopped, restarted, and slowed down; and it can pass on its dynamic stereochemical properties to chiral-at-metal ions through forming organometallic complexes.

The research was led by group members Aisha Bismillah, Toby Johnson, and Burhan Hussein. Congratulations to all the team!

Ruptured Aromaticity in Nature Chemistry

Our investigation of the interplay between strain and aromatic stabilisation energy has been published in Nature Chemistry.

We use peripheral overcrowding to increment the strain energy around an aromatic cation ring (tropylium). Moderate overcrowding causes the tropylium to twist, but beyond a certain strain energy we found that the aromatic ring ruptures to produce a bicyclic ‘Dewar tropylium’ system. Surprisingly, ramping up the strain energy in this way doesn’t appear to diminsh the aromatic stabilisation energy. Instead, the strain and aromaticity can be balanced so the aromatic and nonaromatic isomers exist in rapid, thermal with one another.

The research was led by PhD student Promeet Saha and PDRA Dr Abhijit Mallick. Congratulations to the whole team!

ECR MASC Poster Prize for Promeet

This week the group travelled to Loughborough to attend the fantastic ECR MASC conference (the annual meetings of the RSC’s Macrocyclic and Supramolecular Cheimstry interest group aimed at Early Career Researchers). There were bucketloads of excellent talks and posters from the PhD students and postdocs who had come from supramolecular chemistry groups around the UK.

Congratulations to all of the prize winning contributions, including our very own Promeet Saha, who came away as one of the poster prize winners! Promeet presented a poster about his ‘ruptured aromaticity’ reserach - read more here.

Successes at Durham's Postgraduate Chemistry Symposium

This week we had the pleasure of returning for the first post-pandemic postgraduate symposium in Durham’s Chemistry Department. The whole department was out in force to reconnect over the excellent postgraduate and postdoctoral research talks and posters. Top marks to our PDRA Aisha for leading the event organisation and to those in the group who presented talks (Promeet, Yulong and Senthil) and posters (Yuzhen, Rob, Ash and Ho Chi). Extra congratulations to Promeet and Rob for their well-earned prizes :)

Jack Completes PhD

Congratulations to Jack Williamson who successfully defended his PhD thesis this week! Jack completed his PhD as part of the Soft Matter and Functional Interfaces CDT on the topic of the ‘Synthesis and Material Properties of Aromatic Cation-Centred Compounds‘. External examiner Dr Tom Chamberlain from the Univeristy of Leeds joined internatl examiner Dr Will Brittain for the viva exam. Jack has moved on to a position with Almac in peptide synthesis. Well done Jack!